Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1327)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1056347	0.1075313	0.3371044
Weighted median	23	-0.0708931	0.0557237	0.2032929
Inverse variance weighted	23	-0.0503091	0.0434223	0.2466188
Simple mode	23	-0.1455264	0.0975968	0.1501358
Weighted mode	23	-0.0827401	0.0642087	0.2109201

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.36999	21	0.2754789
Inverse variance weighted	27.25071	22	0.2018585

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0095765	0.0060782	0.1300752

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008761	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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