Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1326)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0973763	0.0998206	0.3404103
Weighted median	23	-0.0346153	0.0584274	0.5535500
Inverse variance weighted	23	-0.0368173	0.0390157	0.3453464
Simple mode	23	-0.0491904	0.1018318	0.6338286
Weighted mode	23	-0.0437005	0.0687390	0.5315002

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.42649	21	0.5578016
Inverse variance weighted	21.55964	22	0.4864202

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0082408	0.0056423	0.1589449

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006803	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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