Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1325)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0536405	0.0998208	0.5966621
Weighted median	23	-0.0189575	0.0523897	0.7174594
Inverse variance weighted	23	-0.0252971	0.0390158	0.5167379
Simple mode	23	-0.0493599	0.0869331	0.5759260
Weighted mode	23	-0.0374257	0.0645409	0.5678901

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.53157	21	0.6784239
Inverse variance weighted	17.62673	22	0.7278757

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017406	0.0056423	0.7607546

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005469	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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