Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1324)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0003249	0.1128801	0.9977308
Weighted median	23	0.0112117	0.0638452	0.8606024
Inverse variance weighted	23	-0.0104254	0.0431164	0.8089385
Simple mode	23	0.0460944	0.1115089	0.6833374
Weighted mode	23	0.0207319	0.0778489	0.7924809

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.85459	21	0.1757182
Inverse variance weighted	26.86828	22	0.2162721

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006602	0.0063805	0.9185744

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008163	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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