Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1323)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0998757	0.1028079	0.3423672
Weighted median	23	0.0126278	0.0574301	0.8259631
Inverse variance weighted	23	-0.0182002	0.0399494	0.6486919
Simple mode	23	-0.0125154	0.0984521	0.8999985
Weighted mode	23	-0.0063816	0.0706999	0.9288946

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.27562	21	0.3837791
Inverse variance weighted	23.06582	22	0.3980208

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050157	0.0058112	0.3978293

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007055	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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