Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1322)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0150642	0.1283744	0.9077009
Weighted median	23	-0.1313074	0.0620321	0.0342799
Inverse variance weighted	23	-0.0633374	0.0492169	0.1981276
Simple mode	23	-0.1816811	0.1067606	0.1028916
Weighted mode	23	-0.1521568	0.0861558	0.0912601

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.73371	21	0.0301937
Inverse variance weighted	35.00976	22	0.0386542

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029645	0.0072564	0.6870184

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011407	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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