Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1321)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0040109	0.1241464	0.9745319
Weighted median	23	-0.0120133	0.0590880	0.8388906
Inverse variance weighted	23	-0.0272867	0.0474551	0.5652910
Simple mode	23	0.0520466	0.1113606	0.6448316
Weighted mode	23	0.0040973	0.0764100	0.9577199

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.48330	21	0.0522698
Inverse variance weighted	32.54748	22	0.0685293

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014294	0.0070174	0.8405562

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010011	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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