Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1320)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0619357	0.0998206	0.5416239
Weighted median	23	0.0381411	0.0557752	0.4940782
Inverse variance weighted	23	0.0401697	0.0390157	0.3032090
Simple mode	23	0.0523937	0.0925347	0.5769844
Weighted mode	23	0.0384287	0.0686671	0.5813800

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.20056	21	0.9340445
Inverse variance weighted	12.25668	22	0.9518492

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0013367	0.0056423	0.8150324

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004035	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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