Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 132)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0433152	0.0998207	0.6687648
Weighted median	23	-0.0118298	0.0543500	0.8276942
Inverse variance weighted	23	-0.0157318	0.0390158	0.6867888
Simple mode	23	-0.0666371	0.1002068	0.5129649
Weighted mode	23	0.0159369	0.0657924	0.8108462

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.77565	21	0.9162786
Inverse variance weighted	12.86578	22	0.9368371

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0016939	0.0056424	0.7669681

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003948	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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