Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1319)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0530716	0.0998200	0.6005318
Weighted median	23	-0.0854024	0.0564451	0.1302753
Inverse variance weighted	23	-0.1147622	0.0390154	0.0032667
Simple mode	23	-0.0828785	0.0966937	0.4006169
Weighted mode	23	-0.0491179	0.0671335	0.4721069

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.05678	21	0.8671479
Inverse variance weighted	14.50760	22	0.8824893

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0037884	0.0056423	0.5092661

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007018	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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