Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1318)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0340254	0.0998200	0.7365896
Weighted median	23	0.0389059	0.0583106	0.5046326
Inverse variance weighted	23	0.0235473	0.0390152	0.5461490
Simple mode	23	0.0559372	0.0953250	0.5633081
Weighted mode	23	0.0513201	0.0736878	0.4934385

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.88513	21	0.5285472
Inverse variance weighted	19.89814	22	0.5894115

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006435	0.0056423	0.9102875

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000614	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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