Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1317)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0033576	0.0998207	0.9734850
Weighted median	23	-0.0078211	0.0534823	0.8837345
Inverse variance weighted	23	-0.0095534	0.0390157	0.8065645
Simple mode	23	-0.0420184	0.0820855	0.6138317
Weighted mode	23	-0.0113084	0.0629901	0.8591670

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.73986	21	0.6654016
Inverse variance weighted	17.75961	22	0.7201421

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007929	0.0056423	0.8895883

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00054	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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