Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1316)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1712347	0.1023709	0.1092223
Weighted median	23	0.0378178	0.0548708	0.4906872
Inverse variance weighted	23	-0.0012563	0.0420961	0.9761917
Simple mode	23	0.0396895	0.0991716	0.6928611
Weighted mode	23	0.0522764	0.0653504	0.4322987

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.08670	21	0.3945287
Inverse variance weighted	25.61113	22	0.2687519

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0105927	0.0057865	0.0813927

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007761	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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