Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1315)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0219905	0.1033198	0.8335048
Weighted median	23	0.0238934	0.0579402	0.6800612
Inverse variance weighted	23	0.0265476	0.0394572	0.5010609
Simple mode	23	0.0719570	0.0998696	0.4787980
Weighted mode	23	0.0426788	0.0815930	0.6061551

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.49855	21	0.3712853
Inverse variance weighted	22.50101	22	0.4303469

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002799	0.0058401	0.9622337

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006959	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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