Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1314)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0673287	0.1109762	0.5505570
Weighted median	23	-0.0603162	0.0622278	0.3324051
Inverse variance weighted	23	-0.0580475	0.0438725	0.1858034
Simple mode	23	-0.0583865	0.1205181	0.6328462
Weighted mode	23	-0.0367366	0.0817677	0.6576245

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.95675	21	0.2081032
Inverse variance weighted	27.81883	22	0.1817632

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0076994	0.0062729	0.2332559

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009101	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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