Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1313)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0094113	0.1137648	0.9348533
Weighted median	23	-0.0014435	0.0626501	0.9816183
Inverse variance weighted	23	0.0271061	0.0434737	0.5329527
Simple mode	23	0.0497959	0.1284269	0.7019366
Weighted mode	23	-0.0387143	0.1015815	0.7067733

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.27836	21	0.1618284
Inverse variance weighted	27.31545	22	0.1994895

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010867	0.0064306	0.8674284

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008424	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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