Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1312)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0000412	0.1301780	0.9997507
Weighted median	23	-0.0009788	0.0570473	0.9863101
Inverse variance weighted	23	0.0233272	0.0497567	0.6391941
Simple mode	23	0.0126128	0.0854490	0.8839984
Weighted mode	23	-0.0009702	0.0594297	0.9871225

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.71579	21	0.0235274
Inverse variance weighted	35.78048	22	0.0320517

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001435	0.0073582	0.8472476

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001095	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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