Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1311)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0625395	0.1065762	0.5635898
Weighted median	23	0.0336660	0.0558200	0.5464309
Inverse variance weighted	23	0.0203365	0.0408771	0.6188342
Simple mode	23	0.0600334	0.0868148	0.4964777
Weighted mode	23	0.0297856	0.0647437	0.6499917

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.93850	21	0.2960478
Inverse variance weighted	24.14948	22	0.3394429

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025917	0.0060242	0.6714241

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00074	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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