Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1310)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0421531	0.0998204	0.6771062
Weighted median	23	-0.0018481	0.0557602	0.9735597
Inverse variance weighted	23	-0.0283562	0.0390157	0.4673543
Simple mode	23	-0.0994025	0.0962042	0.3127145
Weighted mode	23	0.0516662	0.0699086	0.4676872

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.46975	21	0.9528405
Inverse variance weighted	12.05866	22	0.9561558

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.00433	0.0056424	0.4513815

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003814	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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