Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 131)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0029847	0.1065828	0.9779237
Weighted median	23	0.0124498	0.0648182	0.8476851
Inverse variance weighted	23	0.0365813	0.0408583	0.3706157
Simple mode	23	0.0958734	0.1253232	0.4523950
Weighted mode	23	-0.0653228	0.0971940	0.5085257

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.94221	21	0.2958670
Inverse variance weighted	24.12766	22	0.3405737

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024298	0.0060246	0.6908003

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007578	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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