Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1309)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0368560	0.1037085	0.7258492
Weighted median	23	0.0296096	0.0548914	0.5895963
Inverse variance weighted	23	-0.0047507	0.0397818	0.9049440
Simple mode	23	0.0036494	0.0854156	0.9663059
Weighted mode	23	0.0384711	0.0621664	0.5423768

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.66752	21	0.3619583
Inverse variance weighted	22.87258	22	0.4089543

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025551	0.0058621	0.6673858

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006935	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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