Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1308)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0793785	0.1056752	0.4608944
Weighted median	23	-0.0589998	0.0580525	0.3094776
Inverse variance weighted	23	-0.0945485	0.0403775	0.0192005
Simple mode	23	-0.0450224	0.0919584	0.6292665
Weighted mode	23	-0.0450224	0.0650434	0.4960595

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.53559	21	0.3160997
Inverse variance weighted	23.56285	22	0.3705534

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009316	0.0059733	0.8775544

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008919	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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