Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1307)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1588632	0.0998200	0.1264398
Weighted median	23	0.0261975	0.0589810	0.6569203
Inverse variance weighted	23	0.0342383	0.0390154	0.3801823
Simple mode	23	0.0725980	0.1086344	0.5109071
Weighted mode	23	0.0279048	0.0753380	0.7146305

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.77941	21	0.5352695
Inverse variance weighted	21.61922	22	0.4828032

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0076532	0.0056423	0.1893782

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006784	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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