Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1305)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0624577	0.1159843	0.5958938
Weighted median	23	0.0118545	0.0556423	0.8312896
Inverse variance weighted	23	-0.0231982	0.0449647	0.6059103
Simple mode	23	-0.0445164	0.0900555	0.6259788
Weighted mode	23	-0.0022847	0.0611517	0.9705335

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.35143	21	0.1304629
Inverse variance weighted	29.22053	22	0.1386716

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0052601	0.006556	0.4313445

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008961	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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