Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1304)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1278161	0.1172775	0.2881233
Weighted median	23	0.1318336	0.0584652	0.0241392
Inverse variance weighted	23	0.0956366	0.0448794	0.0330918
Simple mode	23	0.1870488	0.1004916	0.0761121
Weighted mode	23	0.1656779	0.0765097	0.0414676

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.98849	21	0.1142781
Inverse variance weighted	29.11116	22	0.1417144

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019762	0.0066291	0.7685551

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010642	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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