Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1303)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0002977	0.0998202	0.9976489
Weighted median	23	0.0277957	0.0575040	0.6288333
Inverse variance weighted	23	0.0305589	0.0390156	0.4334818
Simple mode	23	0.0484329	0.0948922	0.6148549
Weighted mode	23	0.0240947	0.0768082	0.7567045

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.23803	21	0.8108216
Inverse variance weighted	15.34650	22	0.8469436

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018583	0.0056423	0.7451478

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004837	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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