Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1302)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1449007	0.1105478	0.2040958
Weighted median	23	-0.0560282	0.0532742	0.2929398
Inverse variance weighted	23	-0.0137693	0.0438526	0.7535280
Simple mode	23	-0.0248037	0.0806810	0.7614081
Weighted mode	23	-0.0476784	0.0631527	0.4582732

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.75633	21	0.2158931
Inverse variance weighted	27.79326	22	0.1826344

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0080527	0.0062487	0.211515

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008459	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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