Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1301)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0656667	0.1038241	0.5338996
Weighted median	23	-0.0231273	0.0551390	0.6748973
Inverse variance weighted	23	-0.0235975	0.0398299	0.5535440
Simple mode	23	-0.0531939	0.0905460	0.5628635
Weighted mode	23	-0.0325184	0.0651589	0.6226890

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.71824	21	0.3591832
Inverse variance weighted	22.92789	22	0.4058112

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0025835	0.0058686	0.6642789

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007059	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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