Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1300)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1513887	0.1097800	0.1824009
Weighted median	23	-0.0133040	0.0567949	0.8147939
Inverse variance weighted	23	0.0368842	0.0452545	0.4150499
Simple mode	23	0.0185814	0.1032935	0.8588862
Weighted mode	23	-0.0242320	0.0599477	0.6899547

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.39962	21	0.2302714
Inverse variance weighted	29.59852	22	0.1285533

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0115618	0.0062053	0.0764779

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000924	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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