Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 130)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0898532	0.0998199	0.3782459
Weighted median	23	-0.0798540	0.0584796	0.1720952
Inverse variance weighted	23	-0.0194691	0.0390154	0.6177728
Simple mode	23	-0.1494092	0.0979754	0.1415156
Weighted mode	23	-0.0717349	0.0701753	0.3177846

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.49620	21	0.6174237
Inverse variance weighted	19.08303	22	0.6401959

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0043223	0.0056423	0.4521721

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005858	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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