Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 13)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1317643	0.1236545	0.2987104
Weighted median	23	-0.0155013	0.0600312	0.7962365
Inverse variance weighted	23	-0.0495774	0.0478027	0.2996779
Simple mode	23	-0.2234246	0.1116917	0.0579531
Weighted mode	23	-0.1013533	0.0765917	0.1993267

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.22635	21	0.0555313
Inverse variance weighted	33.02651	22	0.0615020

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050471	0.0069896	0.478203

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010497	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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