Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1299)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0515962	0.0998212	0.6106367
Weighted median	23	0.0151395	0.0538054	0.7784227
Inverse variance weighted	23	0.0002876	0.0390158	0.9941187
Simple mode	23	-0.0483174	0.0853044	0.5768470
Weighted mode	23	-0.0001404	0.0624255	0.9982257

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	10.87490	21	0.9651679
Inverse variance weighted	11.19377	22	0.9718739

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0031862	0.0056424	0.578269

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003392	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8