Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1297)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0883450	0.0998211	0.3861606
Weighted median	23	-0.0357978	0.0525776	0.4959620
Inverse variance weighted	23	-0.0424158	0.0390157	0.2769722
Simple mode	23	-0.0200264	0.0916601	0.8290648
Weighted mode	23	-0.0374215	0.0604477	0.5422264

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.94698	21	0.8256029
Inverse variance weighted	15.19686	22	0.8536521

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028205	0.0056424	0.6223575

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004963	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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