Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1296)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1858265	0.1080826	0.1002667
Weighted median	23	-0.0103057	0.0561650	0.8544133
Inverse variance weighted	23	-0.0204770	0.0439045	0.6409295
Simple mode	23	-0.0190675	0.0960174	0.8444123
Weighted mode	23	-0.0156440	0.0645462	0.8107399

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.62047	21	0.2639755
Inverse variance weighted	27.85917	22	0.1803955

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.010154	0.0061093	0.1113571

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008525	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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