Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1295)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0669726	0.1035404	0.5247522
Weighted median	23	0.0134315	0.0567968	0.8130577
Inverse variance weighted	23	0.0087359	0.0398892	0.8266465
Simple mode	23	0.0241822	0.0935255	0.7983763
Weighted mode	23	0.0052819	0.0634251	0.9343841

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.59463	21	0.3659663
Inverse variance weighted	22.99639	22	0.4019337

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035763	0.0058526	0.5477155

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006984	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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