Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1294)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2979529	0.0998181	0.0070602
Weighted median	23	0.1183648	0.0585669	0.0432780
Inverse variance weighted	23	0.0926095	0.0390150	0.0176113
Simple mode	23	0.1130082	0.0984745	0.2634656
Weighted mode	23	0.1374188	0.0680049	0.0556456

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.35543	21	0.8538535
Inverse variance weighted	19.35051	22	0.6235960

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0126103	0.0056423	0.0364145

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007571	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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