Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1293)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1416741	0.1287683	0.2836868
Weighted median	23	0.0292012	0.0658169	0.6572791
Inverse variance weighted	23	-0.0116351	0.0510941	0.8198644
Simple mode	23	-0.1305955	0.1440136	0.3743239
Weighted mode	23	0.0935863	0.0821755	0.2670113

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.94737	21	0.0286128
Inverse variance weighted	37.73164	22	0.0196331

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0094147	0.0072786	0.2098941

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001146	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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