Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1292)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0047742	0.0998209	0.9623057
Weighted median	23	0.0287411	0.0558058	0.6065395
Inverse variance weighted	23	0.0129589	0.0390157	0.7397798
Simple mode	23	0.1303707	0.0890036	0.1571261
Weighted mode	23	0.0275321	0.0597881	0.6496805

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.80829	21	0.7226600
Inverse variance weighted	16.81622	22	0.7734216

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005026	0.0056423	0.9298627

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005129	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8