Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1291)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1161358	0.1374671	0.4077303
Weighted median	23	-0.0030093	0.0585438	0.9590053
Inverse variance weighted	23	0.0216139	0.0539555	0.6887237
Simple mode	23	-0.0291677	0.1074130	0.7885019
Weighted mode	23	-0.0211477	0.0612286	0.7330818

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.82729	21	0.0078047
Inverse variance weighted	42.07502	22	0.0061215

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0084591	0.0077702	0.2886418

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012842	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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