Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1290)

Date: 23 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.1502266 0.1031150 0.1599395
Weighted median 23 0.0316337 0.0584533 0.5883840
Inverse variance weighted 23 0.0611396 0.0401940 0.1282318
Simple mode 23 -0.0045150 0.0965355 0.9631180
Weighted mode 23 0.0256000 0.0676025 0.7085523

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 22.40903 21 0.3762767
Inverse variance weighted 23.34916 22 0.3822435

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0054708 0.0058286 0.3585954

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007819 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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