Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 129)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1753125	0.1021465	0.1008265
Weighted median	23	0.0669058	0.0571769	0.2419392
Inverse variance weighted	23	0.0710961	0.0401319	0.0764671
Simple mode	23	-0.0128378	0.0998058	0.8988210
Weighted mode	23	-0.0098393	0.0773998	0.8999976

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.99052	21	0.4000564
Inverse variance weighted	23.27711	22	0.3862261

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0064	0.0057739	0.2802056

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000806	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8