Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1289)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0817101	0.0998206	0.4222243
Weighted median	23	0.0048940	0.0577160	0.9324253
Inverse variance weighted	23	-0.0334410	0.0390155	0.3913781
Simple mode	23	-0.0402356	0.0958372	0.6786793
Weighted mode	23	0.0057108	0.0681445	0.9339700

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.31671	21	0.7516005
Inverse variance weighted	16.59270	22	0.7854221

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029642	0.0056423	0.604844

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005251	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8