Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1288)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0449579	0.0998210	0.6570478
Weighted median	23	-0.0504100	0.0588471	0.3916506
Inverse variance weighted	23	-0.0231697	0.0390157	0.5526085
Simple mode	23	-0.0994477	0.0957944	0.3104824
Weighted mode	23	-0.0682683	0.0653358	0.3074225

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.55861	21	0.5493522
Inverse variance weighted	20.10841	22	0.5762586

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041837	0.0056424	0.4666132

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00062	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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