Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1287)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2245686	0.1099375	0.0538366
Weighted median	23	-0.0236342	0.0625178	0.7054017
Inverse variance weighted	23	0.0058083	0.0468776	0.9013914
Simple mode	23	-0.1245975	0.1169065	0.2980774
Weighted mode	23	-0.0989933	0.0854653	0.2591668

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.47351	21	0.2272388
Inverse variance weighted	31.76068	22	0.0815687

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0141475	0.0062142	0.0333941

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009631	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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