Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1286)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1182777	0.0998209	0.2492941
Weighted median	23	-0.0263069	0.0532750	0.6214515
Inverse variance weighted	23	-0.0535764	0.0390159	0.1696924
Simple mode	23	-0.0179508	0.0869274	0.8382966
Weighted mode	23	-0.0179508	0.0626981	0.7773225

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.51188	21	0.7402367
Inverse variance weighted	20.01033	22	0.5823937

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0105535	0.0056423	0.07543

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006635	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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