Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1285)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0574407	0.0998204	0.5711085
Weighted median	23	-0.0449861	0.0536940	0.4021296
Inverse variance weighted	23	-0.0560640	0.0390155	0.1507270
Simple mode	23	0.0012586	0.0976263	0.9898304
Weighted mode	23	-0.0530307	0.0630381	0.4092604

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.87098	21	0.7188972
Inverse variance weighted	16.87120	22	0.7704301

Test for directional horizontal pleiotropy

egger_intercept	se	pval
8.45e-05	0.0056423	0.9881862

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005738	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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