Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1284)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1322070	0.1241480	0.2990067
Weighted median	23	-0.0449058	0.0652473	0.4913020
Inverse variance weighted	23	-0.0229936	0.0484293	0.6349398
Simple mode	23	-0.0115716	0.1102063	0.9173275
Weighted mode	23	-0.0404553	0.1234434	0.7462190

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.48626	21	0.0522333
Inverse variance weighted	33.89930	22	0.0502944

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0067069	0.0070176	0.3500809

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010376	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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