Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1283)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1043439	0.0998204	0.3077606
Weighted median	23	0.0107337	0.0557048	0.8472026
Inverse variance weighted	23	0.0204266	0.0390157	0.6005938
Simple mode	23	-0.0554595	0.0944863	0.5632077
Weighted mode	23	-0.0107755	0.0695716	0.8783250

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.81586	21	0.5329501
Inverse variance weighted	21.65996	22	0.4803347

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0076621	0.0056423	0.1888841

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006646	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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