Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1282)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0065149	0.1222979	0.9580196
Weighted median	23	0.0362280	0.0611141	0.5533200
Inverse variance weighted	23	-0.0060945	0.0467022	0.8961724
Simple mode	23	0.0127868	0.1020417	0.9014161
Weighted mode	23	0.0897720	0.0920429	0.3400014

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.52295	21	0.0653843
Inverse variance weighted	31.52297	22	0.0859004

Test for directional horizontal pleiotropy

egger_intercept	se	pval
2.58e-05	0.0069129	0.9970557

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009559	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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