Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1280)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0627560	0.0998209	0.5363339
Weighted median	23	0.0221561	0.0550387	0.6872760
Inverse variance weighted	23	-0.0067894	0.0390158	0.8618523
Simple mode	23	0.0543389	0.0828004	0.5184608
Weighted mode	23	0.0220719	0.0640382	0.7336169

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.06312	21	0.8668729
Inverse variance weighted	14.63603	22	0.8773786

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0042708	0.0056423	0.457511

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004444	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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